Heredity and Genetics

Why do people with CIPA not feel pain?
Answered by Discovery Channel
  • Discovery Channel

    Discovery Channel

  1. Some people say they don't feel pain so that they come off as brave, but there are others who really can't feel when they get hurt. This rare hereditary condition is called congenital insensitivity to pain with anhidrosis, or CIPA. The disorder is one of the hereditary sensory and autonomic neuropathy conditions.

    People with CIPA can't feel physical pain, but they can feel pressure. The reason they don't feel pain is probably because their brains and bodies aren't communicating properly. Normally, nociceptors at the ends of your nerves sense pain and send the message to your brain through electrical impulses along your spine. People with CIPA appear to have working nerve conduction, but they seem to lack the nerve fibers that communicate the messages to their brains.

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