How does the drug U0126 help remove fear memory?
Answered by Science Channel
  • Science Channel

    Science Channel

  1. Researchers, led by Joseph LeDoux of New York University, tried to delete a particular fear memory in rats by disrupting the transfer of that memory from the short-term network to the long-term network. This process is possible because when a memory forms, the brain physically moves that memory from the short-term memory neural network to a long-term memory bank.

    The experiment's premise was that recalling a memory also involves a physical transfer. They successfully removed a specific memory in each of several rats' brains by recalling it while the rats were drugged with U0126 -- a drug that stimulates limited memory loss. At this time, U0126 is not approved for use in humans.

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